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In contrast, the link in between SphK2 and most cancers continues to be not nicely outlined. SphK2 downregulation was more practical than SphK1 downregulation in inhibiting progress of glioblastoma cells 56. Downregulation of SphK2 in MCF7 cells also decreased G2-M arrest and markedly Improved apoptosis induced by doxorubicin, probably due to outco